https://interactiveprotocols.com/index.php/jpro <p>Journal of Pharmaceutical Research and Opinion is a monthly published online Journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest).<br />All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.</p> en-US editor@vcareclinic.info (Dr. Lutchmee Jhummun) editor@vcareclinic.info (Dr Vivekanand Chatap) Sat, 11 Apr 2015 00:00:00 +0000 OJS 3.3.0.13 http://blogs.law.harvard.edu/tech/rss 60 https://interactiveprotocols.com/index.php/jpro/article/view/23 Federal University of Cariri, Divine Savior Street, 284, Center, Barbalha, Ceara, Brazil Kanda R G Copyright (c) 2018 JOURNAL OF RESEARCH & OPINION https://interactiveprotocols.com/index.php/jpro/article/view/23 Sat, 11 Apr 2015 00:00:00 +0000 https://interactiveprotocols.com/index.php/jpro/article/view/24 Background: The studies that focus on the genetic basis of psychopathologies become increasingly frequent and important. Consequently, genetic markers may be the new instrument to assist the diagnostic accuracy of some complex diseases such as Schizophrenia. Aims: To identify the genes those are involved in the schizophrenia’s etiology and their distribution around the world. Methods: we performed a systematic literature research of studies from January 2004 to august 2014 held by SCOPUS and MEDLINE. The descriptors used in both databases were “genetic markers (medical subject headings [MeSH term])”, “mutation (MeSH term)” and “schizophrenia (MeSH term)”. Of the 149 articles found, 39 met the eligibility criteria. RESULTS: Many genetic markers are hypothesized to be linked to Schizophrenia. Genetic studies agree with the clinical observation that schizophrenia is highly heritable but the genetics are complex. Although, some genes such as CAPON, COMT, HUMAN QKI, NR2E1, ProDH and ADRBK2 appears to be frequent in more than one nationality. Conclusion: Therefore, these markers must be studied with larger sample sizes to confirm these promising findings. This study also presents a geographical distribution of the genetic markers around the world with its implications to schizophrenia. Interesting results were observed in the genetic patterns of different ethnicities. However, there remains some doubt about the genes identified and further investigation and wider confirmation are needed as both positive and negative replication studies have been reported in different countries, and it is likely that some initial studies have produced false positives. Kanda R G Copyright (c) 2018 JOURNAL OF RESEARCH & OPINION https://interactiveprotocols.com/index.php/jpro/article/view/24 Sat, 11 Apr 2015 00:00:00 +0000 https://interactiveprotocols.com/index.php/jpro/article/view/22 Introduction: The Northeast Region is the third largest region of Brazil, with 49 million inhabitants, almost 30% of the population, being the second most populated region in the country, behind only Southeast. Investments related to mental health in the Northeast are increasing by the Federal Government. Despite huge investments directed to care to affective disorders, significant losses still occur. Our goal was to address the peculiarities of the evolutionary process of mental health in Brazil and in the Northeast, focusing on the juvenile age group. Method: Original analyzes were performed on secondary data from the Hospital Information System (SIH) belonging to the Unified Health System (SUS) in Brazil, Primary Care Information System (SIAB) and the Brazilian Institute of Geography and Statistics (IBGE). The original data of juvenile mental health were complemented by through the information mapping (Cmap Tools) in the databases: LILACS, SciELO, VHL, MEDLINE. Results: In the Northeast, the precarious socioeconomic conditions contribute to the involvement of children and adolescents with psychopathology. Between 2008 and August 2011, 470 deaths were recorded in mental health in the Northeast. This shows us that not only just create Center for Psychosocial Care-CAPS to improve instantly the health indicators, is still a need for greater training of health professionals who are involved in treating these patients. Conclusions: Some challenges remain in mental health, such as promoting care network, domain and expansion of diagnostic and therapeutic resources, stimulating the social rehabilitation of psychiatric patients, joint approach to mental and socioeconomic status, training of health professionals and interventions in respect to autonomy and the individuality of the bearer of affective disorder. Nádia Nara Rolim Lima Copyright (c) 2018 JOURNAL OF RESEARCH & OPINION https://interactiveprotocols.com/index.php/jpro/article/view/22 Sat, 11 Apr 2015 00:00:00 +0000