Journal of Case Reports and Images

The future of pediatric heart disease cell therapy

Sunaya Krishnapura — Fri, 30 Sep 2022 00:00:00 +0000

Advances in prenatal diagnosis, surgery, interventional cardiology, and medical heart failure management can help
improve the survival rate of children with heart disease. However, long-term morbidity and mortality are still challenging,
especially in children with single-ventricular menstruation and end-stage heart failure. Heart transplantation is the standard care
for children with end-stage heart failure, but the lack of available organs is still a problem worldwide. Therefore, research on
new treatments for advanced heart failure, including mechanical circulation support devices and regenerative therapies, to treat
damaged heart tissue and muscles Perfectly processed over the years, the features show its outstanding performance. Deep deep
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this review, we provide an overview of the current knowledge that exists in the field of cell-based therapies for children with
heart disease, and subsequently It is said about a new strategy that may be implemented in the near future to improve the
efficacy of treatment.

The benefits outweigh the risks of cardiac imaging

Mohab Magdy — Fri, 30 Sep 2022 00:00:00 +0000

The debate about possible risks associated with cardiovascular imaging has intensified. This discussion is triggered by the
increasing use of imaging procedures and methods, including cardiac computed tomography (CT) of the heart. Should doctors
or patients refuse to perform surgery because of the risks associated with cardiac CT? Are the increased costs (due to imaging
procedures) balanced with the benefits of such services to doctors and patients? It is dangerous, especially radiation. However,
the benefits of improved diagnosis and earlier, more effective treatment seem to outweigh the risks.

Single nucleotide polymorphism and left ventricular hypomorphism in Obscurin gene

Arian Ortet — Fri, 30 Sep 2022 00:00:00 +0000

In a recent interesting article, Roland et al. We report a case study
of 4 patients with obscurin mutations, of which 3 had left
ventricular hyperrotation/decompression (LVHT) and 1 patient
had dilated cardiomyopathy [1]. Obscurin interacts with actin,
myomesmin, and obscurin-like-1 to play an important role in the
production of myofibrils and cytoskeletal arrangement, creating a
complex that is important to the function of myofibril M-belt.
The relationship between obscurin variants and LVHT is not
surprising, because the current view is that the contractility of the
heart is related to non-compression. We have the following
opinions and concerns.

SIRT1 activator and its effect on the progression of atherosclerosis

Peng Yanni Xu — Fri, 30 Sep 2022 00:00:00 +0000

Atherosclerosis is the leading cause of cardiovascular disease (CVD) and the leading cause of death worldwide.
Hyperlipidemia and related lipid metabolism disorders are the main risk factors associated with the progression of
atherosclerosis. Sirtuins (SIRT1-SIRT7) are a family of NAD+ dependent deacetylases that catalyze the deacetylation of
histones and non-histone substrates. Among Sirtuins, Sirtuin 1 (SIRT1) has been intensively studied due to its extensive
regulation of life span and cell metabolism. Recently accumulated evidence indicates that the genetic and pharmacological
activation of SIRT1 has a broad preventive effect on atherosclerosis. The discovery of SIRT1 activating compounds (STAC,
SIRT1720, resveratrol, SRT3025, E1231, etc.) is feasible and is becoming a new treatment strategy for the treatment of
atherosclerosis and related cardiovascular diseases (a major fatal senile disease) .

Cardiac CT angiography is an inter-arterial pathway to study the prevalence and short-term results of elderly patients whose right coronary artery originates from the left Valsalva sinus

Mohamed Abdel-shafy Kalim — Fri, 30 Sep 2022 00:00:00 +0000

Purpose: Anomalies of coronary artery origin (ACAOS) in the contralateral Valsalva sinus are common in 1% of common
patients. And 0.4-0.7% of the imaging population. Inter-arterial disease course (IAC) is thought to be related to sudden heart
attacks. Death, especially in young athletes involving abnormalities in the left coronary artery that originated mainly in the
right sinus IAC and Valsalva. The prognosis of Valsalva left sinus and right coronary artery abnormality (R-ACAOS) with
IAC is as follows. Not sure. We aim to evaluate the prevalence and short-term prognosis of R-ACAOS through cardiac
computed tomography Angiography (CCTA).
Methods: This is a single-center retrospective cohort study of 625 consecutive patients who were suspected of being referred
to CCTA. Coronary artery disease (CAD) from January 2012 to December 2017. 10 cases of R-ACAOS were found using
IAC. Each case was matched with two controls of age, gender, CAD severity, cardiovascular risk factors, and history of
revascularization. Measure the results of MACE, including fatal or non-fatal MI, coronary revascularization, or all-cause
death.
Results: The prevalence of R-ACAOS and IAC was 1.6%. The average age of the cases and controls is 65 years. 70% male. so
many The average ± SD time of MACE was 13 ± 15 months and 29 ± 22 months, respectively. The incidence of MACE in the
case and control group was 50% and 40%, respectively. The hazard ratios were: 1.25 (0.055-2.84), P=0.59).
Conclusion: In elderly patients, the short-term prognosis of R-ACAOS with IAC is similar to that of the control group. manage
These patients should be similar to those without R-ACAOS